This conference, with keynote talks by internationally-recognized experts in advance of discussions in breakout sessions and plenary, will set the stage for future risk assessments that go well beyond present localized, primarily single stressor-based assessments, to consider all the stressors affecting our environment and ourselves. Attend to network, learn, contribute in the discussions with or without a poster presentation, and help move the science forward. We are at the cusp of major changes to our planet; the synergies from this meeting and the resulting publications will be pivotal to future science informing national and international policy decision-making.