In this paper I analyse the nexus between cartography, space, and power. Drawing on critical historical cartography and Latour's science studies, I argue that cartography can be seen as an almost universal practice that seeks to make sense of space and the relationship between space and society. The key to the argument is that different modes of cartography establish different spatial realities. And these different spatial realities condition the way in which the space-power nexus can unfold in different ways. The implication of this argument is that space is (of course) not a given reality. Cartography is prioritised as a practice generating spatial realities because it represents a social practice that reverberates between ideas about space, representational practices, and the physical environment. As such cartographic representations not only unveil ideas or discourses about space but they also let the landscape speak to the analysis. As such, cartography establishes space as something that is real, and yet, constructed. The significance of different spatial realities for the exercise of power is illustrated through a historical exposition of the cartographic transition that took place in Europe during the Renaissance, and which allowed space to be organised in novel ways.